What does this research mean for the field?

Calcium-dependent myoblast adhesion, a critical step preceding cell fusion, is mediated by glycoproteins whose carbohydrate residues protect them from proteolytic degradation rather than participating directly in cell-cell adhesion. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1985The Journal of Cell BiologyOpen Access

The calcium-dependent myoblast adhesion that precedes cell fusion is mediated by glycoproteins.

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Population

Presumptive myoblasts from explants of chick embryo pectoral muscle

Comparison

Inhibitors of myotube formation, trypsin… vs Control conditions

Design

Preclinical

Authors

KKKaroline KnudsenAarhus University

Discussion

Member takes

Implication

Hypothesis-generating in animal myoblasts; leaves open relevance to human muscle fusion or regeneration.

Structured PICO

Population

Presumptive myoblasts from explants of chick embryo pectoral muscle

Intervention

Inhibitors of myotube formation (trifluoperazine, sodium butyrate, chloroquine, 1,10 phenanthroline, and tunicamycin), trypsin treatment, and antiserum against fusion-competent myoblasts

Comparator

Control conditions (absence of inhibitors, presence/absence of Ca++)

Outcome

Ca++-dependent myoblast adhesion and myotube formation (fusion)surrogate

Ca++-dependent myoblast adhesion prior to cell fusion is mediated by glycoproteins whose carbohydrate residues protect them from proteolytic degradation.

Cite This Study

Karoline Knudsen (1985) studied this question.

synapsesocial.com/papers/6a1e38c709554abc3868a3ad https://doi.org/10.1083/jcb.101.3.891

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Bookmark

The calcium-dependent myoblast adhesion that precedes cell fusion is mediated by glycoproteins.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The calcium-dependent myoblast adhesion that precedes cell fusion is mediated by glycoproteins.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider