What is the clinical evidence from this study?

Study design: Case Report. Population: Hypertrophic cardiomyopathy (n=1). Intervention: Cardiac Magnetic Resonance.

What does this research mean for the field?

Hypertrophic cardiomyopathy can present as an isolated and atypical hypertrophy of the mid-basal inferior left ventricular wall, requiring Cardiac Magnetic Resonance for accurate diagnosis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe an atypical presentation of hypertrophic cardiomyopathy confined strictly to the mid-basal inferior left ventricular wall following presentation with unstable ventricular tachycardia.

September 15, 2026European Heart Journal Supplements

Inferior Hypertrophic Cardiomyopathy: An Unusual and Subtle Location

Q: What are the key findings of this study?

Cardiac Magnetic Resonance successfully diagnosed a highly unusual case of isolated inferior hypertrophic cardiomyopathy in a 64-year-old woman presenting with wide-complex tachycardia.

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Key result

CMR identifies a rare case of isolated inferior HCM presenting with wide-complex tachycardia.

Key Points

To describe an atypical presentation of hypertrophic cardiomyopathy confined strictly to the mid-basal inferior left ventricular wall following presentation with unstable ventricular tachycardia.
Evaluated a 64-year-old female presenting with wide-complex tachycardia using electrocardiography, electrical cardioversion, and bedside transthoracic echocardiography.
Performed invasive coronary angiography to rule out obstructive coronary artery disease, followed by cardiac magnetic resonance (CMR) imaging with late gadolinium enhancement (LGE) and T1 mapping.
Bedside echocardiography and coronary angiography identified mid-basal inferior hypo-akinesia and normal coronary arteries without obstructive lesions.
Cardiac magnetic resonance demonstrated isolated mid-basal inferior wall hypertrophy measuring 18 mm, transmural late gadolinium enhancement, and elevated T1 mapping values (1098 ms vs. <994 ms in normal myocardium), confirming the diagnosis and leading to implantable cardioverter-defibrillator placement.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A 64-year-old obese Caucasian female presenting with wide-complex tachycardia diagnosed with isolated inferior hypertrophic cardiomyopathy.

Exposure

Cardiac Magnetic Resonance (CMR) imaging and subsequent implantable cardioverter-defibrillator (ICD) placement

Outcome

Diagnosis of isolated inferior hypertrophic cardiomyopathy

Cardiac Magnetic Resonance plays a pivotal diagnostic role in identifying atypical and focal variants of hypertrophic cardiomyopathy, such as isolated inferior wall involvement, which may be missed by echocardiography.

Discussion

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Implication

Awareness of rare inferior-wall HCM variants aids differential diagnosis; leaves open systematic prevalence and outcome data.

Cite This Study

Pancaldo et al. (2026) conducted a case report in Hypertrophic cardiomyopathy (n=1). Cardiac Magnetic Resonance was evaluated. Cardiac Magnetic Resonance successfully diagnosed a highly unusual case of isolated inferior hypertrophic cardiomyopathy in a 64-year-old woman presenting with wide-complex tachycardia.

synapsesocial.com/papers/6aa9016aeed42882c1fc1895 https://doi.org/10.1093/eurheartjsupp/suag058.296

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Inferior Hypertrophic Cardiomyopathy: An Unusual and Subtle Location

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Inferior Hypertrophic Cardiomyopathy: An Unusual and Subtle Location

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider