What does this research mean for the field?

Giant right atrial angiosarcoma can present with non-specific symptoms such as dyspnea and atrial flutter, and may require multimodality imaging combined with direct cardiac biopsy for definitive diagnosis when extra-cardiac biopsies are inconclusive. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe the complex diagnostic pathway and multimodal imaging characteristics of a rare, giant primary cardiac angiosarcoma in the right atrium.

September 15, 2026European Heart Journal Supplements

Giant Atrial Angiosarcoma: A Challenging Diagnosis

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Cardiac angiosarcoma (n=1). Intervention: Diagnostic workup including direct right atrial biopsy. Primary outcome: Definitive diagnosis of conventional angiosarcoma.

View Full Paper

Ask AI

Bookmark

Key result

Multimodality imaging and direct biopsy definitively identify a giant right atrial mass as conventional angiosarcoma.

Population

A 70-year-old woman admitted with dyspnea and palpitations

Design

Case report

Authors

PMP MilewskiOspedale regionale di Lugano ACA ComunelloOspedale regionale di Lugano CLC LadurnerOspedale regionale di Lugano

Discussion

Member takes

Implication

Targeted biopsy is key for confirming right atrial angiosarcoma; extends sparse case-level data on multimodal imaging in elderly patients.

Key Points

To describe the complex diagnostic pathway and multimodal imaging characteristics of a rare, giant primary cardiac angiosarcoma in the right atrium.
Clinical and diagnostic workup of a 70-year-old woman presenting with atrial flutter, dyspnea, and palpitations.
Sequential imaging assessment using transthoracic echocardiography, contrast-enhanced CT, whole-body FDG-PET, and cardiac MRI.
Histopathological investigation through an initial percutaneous liver biopsy followed by a direct right atrial mass biopsy.
Diagnostic imaging revealed a 57×46×65 mm hypervascular mass infiltrating the right atrial free wall, right atrioventricular sulcus, right coronary artery, and right ventricle with patchy late gadolinium enhancement.
While an initial liver biopsy was non-diagnostic, direct right atrial biopsy confirmed conventional angiosarcoma, allowing referral to oncology for systemic chemotherapy.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A 70-year-old woman presenting with dyspnea and palpitations diagnosed with a giant right atrial angiosarcoma.

Exposure

Multimodality imaging (transthoracic echocardiography, CT, FDG-PET, cardiac MRI) and direct right atrial biopsy.

Outcome

Definitive diagnosis of conventional angiosarcoma.

This case highlights the importance of multimodality imaging and direct tissue biopsy in the challenging diagnosis of cardiac angiosarcoma.

Cite This Study

Milewski et al. (2026) conducted a case report in Cardiac angiosarcoma (n=1). Diagnostic workup including direct right atrial biopsy was evaluated on Definitive diagnosis of conventional angiosarcoma. A 70-year-old woman with a giant right atrial mass was definitively diagnosed with conventional angiosarcoma following multimodality imaging and a direct right atrial biopsy.

synapsesocial.com/papers/6aa9017deed42882c1fc18ff https://doi.org/10.1093/eurheartjsupp/suag058.320

View Full Paper

Ask AI

Bookmark

Implication

Targeted biopsy is key for confirming right atrial angiosarcoma; extends sparse case-level data on multimodal imaging in elderly patients.

Giant Atrial Angiosarcoma: A Challenging Diagnosis

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Giant Atrial Angiosarcoma: A Challenging Diagnosis

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider