Key result
Right atrial cardioneuroablation linked to ~88% fewer asystolic episodes and less syncope.
Why the study?
Cardioneuroablation should focus on the vagal ganglia located in the right atrium close to the sinoatrial and atrioventricular nodes, but the efficacy and safety of right atrial CNA required evaluation.
Does right atrial cardioneuroablation reduce asystolic and syncopal episodes in patients with severe asystolic reflex syncope?
Cohort (n=28)
Does right atrial cardioneuroablation reduce asystolic and syncopal episodes in patients with severe asystolic reflex syncope?
Relative Risk: 0.12
Absolute Event Rate: 0.11% vs 0.89%
p-value: p=0.0001
Right atrial cardioneuroablation significantly reduces the burden of asystolic and syncopal episodes in patients with severe asystolic reflex syncope, with a favorable safety profile.
No takes yet. Share an insight, caveat, or question.
May support consideration in refractory asystolic syncope; leaves open need for randomized trials to confirm benefit.
Giamundo et al. (2026) conducted a cohort in Severe, asystolic reflex syncope (n=28). Right atrial cardioneuroablation (CNA) vs. Before CNA (baseline) was evaluated on Burden of asystolic episodes (episodes per month) (RR 0.12, p=0.0001). Right atrial cardioneuroablation reduced the burden of asystolic episodes from 0.89 to 0.11 per month (RR 0.12, P=0.0001) and syncopal episodes by 76% over a median 12.5-month follow-up.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: