Key result
Norepinephrine plus beta-1 blockers reduce LVOTO and stabilize hemodynamics in a severe MR case.
Why the study?
Dynamic LVOTO due to SAM causes mitral regurgitation that can potentially hide structural valve disease.
Case Report (n=1)
In patients with cardiogenic shock and severe mitral regurgitation complicated by dynamic LVOTO, hemodynamic modulation with norepinephrine and beta-blockers can stabilize the patient and unmask underlying structural abnormalities such as endocarditis.
May stabilize shock with LVOTO and severe MR while unmasking endocarditis; hypothesis-generating from single case report.
Introduction dynamic left ventricular outflow tract obstruction (LVOTO) due to systolic anterior motion (SAM) causes various grades of mitral regurgitation (MR), potentially hiding structural valve disease. Case report we present a case of an 82–year–old patient admitted to cardiac intensive care unit (CICU) due to cardiogenic shock and acute respiratory failure caused by severe MR, hiding mitral valve vegetation. MR resulted from flail and perforation of posterior mitral leaflet (PML), combined with dynamic LVOTO due SAM of anterior mitral leaflet (AML). Discussion careful avoidance of same therapy and devices indicated in MR, like sodium nitroprusside and intra–aortic balloon pump (IABP), is essential to avoid worsening of LVOTO and thus hemodynamic stability. Instead, the use of drugs to obtain pressure equalization and negative chronotropism, such as norepinephrine and selective beta–1 receptor blockers, significantly reduce LVOTO and thus the MR, achieving hemodynamic stability and showing valve anatomy. Conclusion our case–report underscores the importance of a multidisciplinary approach in the management of complex valvular dysfunction, particularly when dynamic LVOTO complicates the clinical presentation. Careful hemodynamic modulation can not only improve patient stability but also facilitate accurate diagnostic assessment, ensuring timely and appropriate therapeutic interventions. Keywords: dynamic left ventricular outflow tract obstruction, systolic anterior motion (SAM), mitral regurgitation, endocarditis, shock, valvular heart disease. Contribution type: case report
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Bonnì et al. (2026) conducted a case report in Endocarditis with severe mitral regurgitation and dynamic left ventricular outflow tract obstruction (n=1). Norepinephrine and selective beta-1 receptor blockers was evaluated on Hemodynamic stability and reduction of LVOTO. Administration of norepinephrine and selective beta-1 receptor blockers reduced LVOTO and achieved hemodynamic stability in a patient with severe mitral regurgitation and hidden endocarditis.
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