Key result
Nasogastric decompression normalizes ST-elevation mimicking acute MI within 15 minutes in severe gastrointestinal distension.
Why the study?
Extracardiac conditions can produce pseudo-ischemic electrocardiographic patterns mimicking acute coronary occlusion, posing diagnostic challenges and risking unnecessary invasive procedures.
Case Report (n=1)
Severe gastrointestinal distension is a rare cause of transient ST-segment elevation mimicking acute myocardial infarction, which can be distinguished from true ischemia using clinical presentation, biomarkers, and echocardiography.
ST-segment elevation with abdominal distension warrants GI decompression consideration before catheterization; this case leaves open broader validation of extracardiac mimics.
Background ST–segment elevation on electrocardiography is commonly interpreted as a marker of acute coronary artery occlusion. However, extracardiac conditions may occasionally produce pseudo–ischemic electrocardiographic patterns, posing significant diagnostic challenges and increasing the risk of unnecessary invasive procedures. Case presentation We report the case of a 68–year–old man with a history of inferior myocardial infarction who presented to the emergency department with severe abdominal distension due to a closed–loop small bowel obstruction. Despite the absence of chest pain or cardiopulmonary symptoms, the admission electrocardiogram showed marked anterolateral ST–segment elevation fulfilling diagnostic criteria for ST–elevation myocardial infarction. High–sensitivity troponin levels were negative. Prompt transthoracic echocardiography demonstrated preserved anterior wall motion, chronic inferior akinesia consistent with prior infarction, and unchanged global longitudinal strain, effectively excluding acute myocardial ischemia. Nasogastric decompression led to rapid resolution of abdominal distension and complete normalization of ST–segment elevation within fifteen minutes. Subsequent abdominal imaging confirmed a closed–loop volvulus requiring urgent surgical intervention, with full bowel viability preserved after adhesiolysis. Conclusions This case highlights severe gastrointestinal distension as a rare but clinically relevant cause of transient ST–segment elevation mimicking acute myocardial infarction. Integration of clinical presentation, cardiac biomarkers, and rapid echocardiographic assessment, including strain imaging, is crucial to distinguish pseudo–STEMI from true ischemic events. Recognizing extracardiac causes of ST–segment elevation may prevent unnecessary coronary angiography while ensuring timely management of underlying surgical emergencies.
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Cacciapuoti et al. (2026) conducted a case report in Pseudo-STEMI (n=1). Severe intestinal distension was evaluated. Severe gastrointestinal distension caused transient ST-segment elevation mimicking acute myocardial infarction, which completely normalized within 15 minutes of nasogastric decompression.
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