What question did this study set out to answer?

Characterize the proteogenomic landscape of primary breast cancers to uncover functional signaling networks, post-translational modifications, and predictive biomarkers for targeted therapies.

November 1, 2020CellOpen Access

Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy

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Authors

KKKarsten KrugFrontier Aerospace Corporation (United States)EJEric J. JaehnigBaylor College of Medicine SSShankha SatpathyBroad Institute

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Implication

Proteogenomic analysis uncovers targetable kinase vulnerabilities and metabolic cross-talk in treatment-naive primary breast cancers, highlighting avenues for personalized targeted therapy.

Key Points

Characterize the proteogenomic landscape of primary breast cancers to uncover functional signaling networks, post-translational modifications, and predictive biomarkers for targeted therapies.
Integrated mass spectrometry-based proteomics, phosphoproteomics, and acetylproteomics with next-generation DNA and RNA sequencing.
Profiled N=122 treatment-naive primary breast cancer specimens preserved specifically to retain protein phosphorylation and acetylation modifications.
Proteogenomic profiling refined standard breast cancer diagnoses, clarified ERBB2 amplicon architecture, and enhanced Rb status evaluation to predict CDK4/6 inhibitor responsiveness.
Phosphoproteomic analysis revealed novel associations between tumor suppressor loss and actionable kinases, alongside subsets candidates for immune checkpoint blockade.
Acetylproteome characterization identified modifications on critical DNA repair proteins and demonstrated regulatory cross-talk between mitochondrial metabolism and cytoplasmic acetylation.

Cite This Study

Krug et al. (2020) studied this question.

synapsesocial.com/papers/6aa9032cbc25ca06ee299b9d https://doi.org/10.1016/j.cell.2020.10.036

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Implication

Proteogenomic analysis uncovers targetable kinase vulnerabilities and metabolic cross-talk in treatment-naive primary breast cancers, highlighting avenues for personalized targeted therapy.

Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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