What question did this study set out to answer?

To assess how the breadth and specificities of memory cytotoxic T lymphocytes correlate with viral load and clinical disease progression during chronic HIV infection.

December 1, 2002AIDS

Correlation between breadth of memory HIV-specific cytotoxic T cells, viral load and disease progression in HIV infection

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Authors

CCCécile ChouquetCentre National de la Recherche Scientifique BABrigitte AutranInserm EGE GomardHôpital Cochin

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Implication

Prospective cohort study reveals broader memory cytotoxic T-cell responses lower viral load in chronic HIV, indicating key targets for protective vaccines.

Key Points

To assess how the breadth and specificities of memory cytotoxic T lymphocytes correlate with viral load and clinical disease progression during chronic HIV infection.
Prospective 5-year follow-up cohort of 148 chronically infected, antiretroviral-naive individuals enrolled before the availability of highly active antiretroviral therapy.
Memory cytotoxic T lymphocytes were measured in vitro against autologous target cells expressing HIV-LAI proteins (Env, Gag, Pol, Nef, Vif, Rev, and Tat).
Multivariate longitudinal analysis was conducted to examine changes in antigen recognition over time and evaluate correlations with viral load, CD4/CD8 counts, and opportunistic infections.
At baseline, 77% of participants exhibited cytotoxic T-cell responses to at least one viral protein, predominantly targeting Pol (57%), Gag (57%), Env (36%), and Nef (30%).
Longitudinal multivariate modeling showed the average baseline recognition of two proteins decreased significantly over time, with an average loss of one protein recognition per 7 years.
The breadth of recognized proteins was inversely correlated with viral load (P < 0.05) and opportunistic infection onset (P < 0.01), and positively associated with CD8 cell counts (P < 0.05), but not CD4 counts.

Cite This Study

Chouquet et al. (2002) studied this question.

synapsesocial.com/papers/6aa9051d39e8b1c7dca34440 https://doi.org/10.1097/00002030-200212060-00004

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Implication

Prospective cohort study reveals broader memory cytotoxic T-cell responses lower viral load in chronic HIV, indicating key targets for protective vaccines.

Correlation between breadth of memory HIV-specific cytotoxic T cells, viral load and disease progression in HIV infection

Discussion

Member takes

Implication

Key Points

Cite This Study

Correlation between breadth of memory HIV-specific cytotoxic T cells, viral load and disease progression in HIV infection

Discussion

Member takes

Implication

Key Points

Cite This Study

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