Targeting the oral microbiome: Delivery of Lactobacillus paracasei through orodispersible tablets

With increasing interest in probiotic-based strategies for oral health, Lactobacillus paracasei ( L. paracasei ) has emerged as a potent candidate for controlling oral dysbiosis. Recent pre-clinical and clinical evidences support the use of L. paracasei , particularly in the context of its delivery through orodispersible tablets (ODTs). Studies consistently report reductions in Streptococcus mutans , improvements in gingival health, and suppression of plaque regrowth with L. paracasei -based interventions. As a user-friendly and targeted delivery platform, ODTs ensure direct mucosal contact and improved patient compliance, especially in pediatric and geriatric populations. This short communication highlights the mechanisms, benefits, and prospects of ODT-based delivery of L. paracasei in oral care.