Key result
HDL-apoA-I exchange linked to ~11% lower major CVD risk and less atherosclerotic burden.
Why the study?
Measures of HDL function are emerging tools for assessing cardiovascular disease event risk in type 2 diabetes but their association with atherosclerotic burden and outcomes is not well established.
Does HDL-apoA-I exchange (HAE) predict atherosclerotic burden and major CVD events in patients with type 2 diabetes and at least one additional CVD risk factor?
Cohort (n=93)
Does HDL-apoA-I exchange (HAE) predict atherosclerotic burden and major CVD events in patients with type 2 diabetes and at least one additional CVD risk factor?
HDL-apoA-I exchange (HAE) is inversely associated with atherosclerotic burden and major cardiovascular events in patients with type 2 diabetes, suggesting its utility as a biomarker for CVD risk.
HAE may refine risk stratification in type 2 diabetes; hypothesis-generating and should not yet change practice.
BACKGROUND AND AIMS: Measures of HDL function are emerging tools for assessing cardiovascular disease (CVD) event risk. HDL-apoA-I exchange (HAE) reflects HDL capacity for reverse cholesterol transport. METHODS: HAE was measured in 93 participants with type 2 diabetes (T2D) and at least one additional CVD risk factor in the Asker and Bærum Cardiovascular Diabetes study. At baseline and after seven years, the atherosclerotic burden was assessed by invasive coronary angiography. Major CVD events were registered throughout the study. RESULTS: Linear regression analysis demonstrated a significant inverse association between HAE and atherosclerotic burden. Cox proportional hazard regression analysis showed a significant association between HAE and a composite of major CVD events when controlling for waist-hip ratio, HR = 0.89, 95% CI = 0.80-1.00 and p=0.040. CONCLUSIONS: Despite the relatively small size of the study population and the limited number of CVD events, these findings suggest that HAE provides valuable information in determining CVD risk.
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Heier et al. (2018) conducted a cohort in Type 2 diabetes (n=93). HDL-apoA-I exchange (HAE) was evaluated on Composite of major CVD events (HR 0.89, 95% CI 0.80-1.00, p=0.040). HDL-apoA-I exchange (HAE) was significantly associated with a lower risk of major CVD events (HR 0.89; 95% CI 0.80-1.00; p=0.040) and inversely associated with atherosclerotic burden.
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