Key result
Dystrophin glycoprotein complex disruption leads to muscle membrane instability and disease.
Why the study?
Proper synthesis and positioning of the dystrophin glycoprotein complex are essential for sarcolemmal function, and its perturbation leads to muscle membrane instability and disease.
Population
Skeletal muscle fibers and cells
Design
Review
Authors
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DGC integrity underpins membrane stability in dystrophy; reinforces mechanistic consensus while leaving open targeted cardiac therapies.
Normal sarcolemmal function requires proper DGC synthesis and positioning, and perturbation of the DGC leads to muscle membrane instability and disease.
Allikian et al. (2006) conducted a review in Muscle membrane instability and disease. Normal sarcolemmal function requires proper synthesis and positioning of the dystrophin glycoprotein complex, and its perturbation leads to muscle membrane instability and disease.
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