This case highlights the diagnostic challenge of distinguishing a primary malignant fibrous histiocytoma of the lung from a solitary metastasis in a patient with multiple primary tumors.
A case of primary malignant myxoid fibrous histiocytoma of the lung presenting as a solitary lung nodule in a 61-year-old man is presented. This tumor arose in a patient with a transitional-cell carcinoma of the urinary bladder and a well differentiated squamous-cell carcinoma of the larynx. The differential diagnosis between a primary lung tumor, versus a solitary metastasis is difficult and was supported by histological features and the lack of epithelial properties proved by immunohistochemistry. Tobacco was the only etiologic factor known in the patient.
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Gómez‐Román et al. (1996) studied this question.
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