Key result
Three anoikis-related genes strongly discriminate aortic dissection from healthy controls with up to ~0.92 AUC.
Why the study?
The pathogenesis of aortic dissection remains unclear, which may affect or delay diagnosis.
Effect estimate: AUC 0.919 for GRSF1, 0.906 for TP53, 0.889 for TUBB3
TP53 and TUBB3 were identified as potential anoikis-related diagnostic biomarkers for aortic dissection using machine learning and bioinformatics analysis.
May support aortic dissection diagnostics; hypothesis-generating and requires prospective validation before clinical use.
Aortic dissection (AD) is one of the most dangerous diseases of the cardiovascular system, which is characterized by acute onset and poor prognosis, while the pathogenesis of AD is still unclear and may affect or even delay the diagnosis of AD. Anchorage-dependent cell death (Anoikis) is a special mode of cell death, which is programmed cell death caused by normal cells after detachment from extracellular matrix (ECM) and has been widely studied in the field of oncology in recent years. In this study, we applied bioinformatics analysis, according to the results of research analysis and Gene Ontology (GO), as well as Kyoto Encyclopedia of Genes and Genomes (KEGG), finally found 3 anoikis-related genes (ARGs) based on machine learning. Among these, TP53 and TUBB3 were further verified by receiver operating characteristic (ROC), gene set enrichment analysis (GSEA), gene set variation analysis (GSVA)and other methods. We hypothesize ARGs may be involved in the pathogenesis of AD through pathways such as oxidative stress, inflammatory response, and ECM. Therefore, we conclude that these ARGs can be potential factors in determining the diagnosis of AD.
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Zhang et al. (2024) studied Aortic dissection. Anoikis-related genes (GRSF1, TP53, TUBB3) vs. Healthy controls was evaluated on Diagnostic capability (Area Under Curve) for aortic dissection (AUC 0.919 for GRSF1, 0.906 for TP53, 0.889 for TUBB3). Three anoikis-related genes (GRSF1, TP53, and TUBB3) demonstrated strong diagnostic discriminative power between aortic dissection cases and healthy controls, with AUCs of 0.919, 0.906, and 0.889, respectively.
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