Key result
Polycystic ovary syndrome was strongly associated with pathological HbA1c levels (≥ 6.5%) compared to controls (60% vs. 7.7%, OR 14.79) in Congolese women.
Why the study?
PCOS is linked to metabolic syndrome and diabetes risk, but the HbA1c profile, hyperglycemia frequency, and impact on clinical signs in Congolese women remained to be determined.
Is polycystic ovary syndrome associated with elevated HbA1c levels in Congolese subfertile women?
Case-Control (n=130)
Yes
Is polycystic ovary syndrome associated with elevated HbA1c levels in Congolese subfertile women?
In Congolese subfertile women, PCOS is strongly associated with elevated HbA1c levels, indicating a high prevalence of hyperglycemia in this population.
Answers are grounded in this paper and cite their sources.
Elevated HbA1c may indicate higher hyperglycemia risk in Congolese women with PCOS; leaves open need for prospective validation before screening changes.
Context: Polycystic ovary syndrome (PCOS) is considered a syndrome related to the metabolic syndrome with a high risk for developing diabetes mellitus. The evaluation of the glycated hemoglobin (HbA1c) seems to be an interesting tool to detect states of hyperglycemia that may be associated with this syndrome and to understand her pathophysiology. Aims: The purposes of this study are to determine the profile of HbA1c in Congolese women with PCOS, to determine the frequency of states of hyperglycemia and to assess the impact of this marker on clinical signs on this syndrome. Material and methods: This is a case-control study of 130 Congolese subfertile women; 65 with a diagnosis of PCOS and 65 others without PCOS. This is conducted from June 2016 to June 2019 among Congolese women of childbearing age. All these women were recruited at the subfertility outpatient clinic of the University Hospital of UNIKIN as well of the YANGA medical centers in Kinshasa, Democratic Republic of Congo. Sickle cell disease was excluded as also the cases of anemia. HbA1c was assayed via the immunoturbidimetric method and the results interpreted according to the ADA recommendations with a pathological cut-off point ≥ 6.5%. Results: Mean hemoglobin was 11.6 ± 1.2 g/dl (11.5 ± 1.1 g/dl vs. 11.8 ± 1.4 g/dl, P = 0.568). The proportion of diabetics was 1.6% (1.6% vs. 1.5%, P = 0.74). Higher HbA1c values were noted in the PCOS group compared to the control group (7.3% ± 2.1% vs. 5.6% ± 0.6%, P 0.001). The multivariate analysis showed a strong correlation between elevated HbA1c levels and PCOS (OR 14.79 (CI 5.43 - 40.32), P 0.001). In the PCOS group, higher HbA1c values were significantly correlated with a higher socio-economic status (OR 3.38 (1.67 - 8.47), P = 0.018) and with obesity (OR 3.48 IC (1.31 - 7.13) P = 0.029). A perfect, positive and significant linear correlation was found between HbA1c and fasting blood glucose (r = 0.807). 60% of women in the PCOS group had pathological values of HbA1c (≥6.5%) co
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Numbi et al. (2019) conducted a case-control in Polycystic Ovary Syndrome (PCOS) (n=130). Polycystic Ovary Syndrome vs. Women without PCOS was evaluated on Pathological HbA1c values (≥ 6.5%) (OR 14.79, 95% CI 5.43-40.32, p=<0.001). Polycystic ovary syndrome was strongly associated with pathological HbA1c levels (≥ 6.5%) compared to controls (60% vs. 7.7%, OR 14.79) in Congolese women.
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