Key result
TIMI frame count inversely correlates with peak velocity but cannot accurately assess post-angioplasty microvascular injury.
Why the study?
The relation between TIMI frame count and coronary blood flow velocity parameters reflecting microvascular injury after primary coronary angioplasty in acute myocardial infarction patients was unclear.
Does TIMI frame count accurately reflect the degree of microvascular injury assessed by coronary blood flow velocity after primary coronary angioplasty in patients with acute anterior myocardial infarction?
Observational (n=103)
Does TIMI frame count accurately reflect the degree of microvascular injury assessed by coronary blood flow velocity after primary coronary angioplasty in patients with acute anterior myocardial infarction?
Effect estimate: r = -0.43
p-value: p=<0.0001
TIMI frame count reflects epicardial coronary blood flow velocity but is not accurate enough to assess the degree of microvascular injury after primary coronary angioplasty.
TIMI frame count should not guide microvascular injury assessment after primary angioplasty; leaves open whether refined angiographic indices merit prospective validation.
OBJECTIVE: To investigate the relation between thrombolysis in myocardial infarction (TIMI) frame count (TFC) and coronary blood flow velocity (CBFV) parameters reflecting the degree of microvascular injury in patients with acute myocardial infarction. RESULTS: TFC and CBFV were measured after primary coronary angioplasty in 103 consecutive patients with their first anterior wall acute myocardial infarction. TFC correlated inversely with the averaged peak velocity (r = -0.43, p < 0.0001). However, TFC did not correlate significantly with diastolic deceleration time and with the averaged systolic peak velocity (r = -0.16, p = 0.22, and r = -0.23, p = 0.16, respectively). The patients were divided into two groups according to presence (35 patients) or absence (68 patients) of systolic flow reversal. There was no significant difference in TFC between the two groups (29 (16) v 25 (13), p = 0.20). CONCLUSIONS: These findings suggest that the TFC reflects epicardial CBFV. However, it is not accurate enough to assess the degree of microvascular injury after primary coronary angioplasty.
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Yoshikazu Ohara (2004) conducted an observational in acute anterior myocardial infarction (n=103). TIMI frame count (TFC) was evaluated on Correlation between TIMI frame count and averaged peak velocity (r = -0.43, p=<0.0001). TIMI frame count correlated inversely with averaged peak velocity (r = -0.43, p < 0.0001) but was not accurate enough to assess microvascular injury after primary coronary angioplasty.
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