Key result
Optimal disease control and risk factor monitoring reduce cardiovascular morbidity and mortality in rheumatoid arthritis.
Why the study?
Rheumatoid arthritis is recognized as an independent risk factor for cardiovascular disease with about twofold higher risk, making early risk assessment and management crucial to reduce morbidity and mortality.
Does management of CVD risk factors and optimal control of disease activity reduce cardiovascular morbidity and mortality in patients with rheumatoid arthritis?
Systematic Review
Does management of CVD risk factors and optimal control of disease activity reduce cardiovascular morbidity and mortality in patients with rheumatoid arthritis?
Optimal control of disease activity and persistent monitoring of risk factors are crucial for managing cardiovascular risk in patients with rheumatoid arthritis.
Warrants routine CV risk assessment in RA; confirms independent twofold CVD elevation and extends calls for integrated prevention trials.
Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory joint disease associated with pain, swelling, and morning stiffness. It not only affects the joints but also exhibits many extra-articular manifestations. It is recognized as an independent risk factor for cardiovascular (CV) abnormalities. The possibility of cardiovascular disease (CVD) risk in patients with RA is about twofold higher compared to non-RA individuals. Therefore, early risk assessment and management of risk factors are crucial to reduce the CV morbidity and mortality associated with RA. This systematic literature review summarizes the data available on the management of CVD risk factors in RA. A total of 61 articles from the most reputable journals published between 2013 and 2023 were reviewed, of which seven papers were selected for in-depth analysis. We tried to eliminate bias using various bias-eliminating tools. This analysis considers the proposed solution for CV risk prevention and management in RA patients. Optimal control of disease activity and persistent monitoring of other factors responsible for increased CV events in RA patients is the ultimate management of CV abnormalities. This study summarizes the recommendations for the management of CV risk factors in patients with RA.
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Singh et al. (2024) conducted a systematic review in Rheumatoid arthritis. Cardiovascular risk management (DMARDs, statins, antihypertensives, lifestyle modifications) was evaluated on Cardiovascular risk reduction and management. Optimal control of disease activity and persistent monitoring of traditional risk factors are crucial to reduce cardiovascular morbidity and mortality associated with rheumatoid arthritis.
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