Key result
Lower plasma Protein Z discriminates HELLP syndrome from normal pregnancy at a 1330 ng/mL cutoff.
Why the study?
Are plasma concentrations of Protein Z associated with HELLP syndrome and its severity?
Case-Control (n=83)
Are plasma concentrations of Protein Z associated with HELLP syndrome and its severity?
Low Protein Z levels are associated with HELLP syndrome and its severity, suggesting a potential role in its pathobiology and utility as a biomarker.
Low Protein Z supports biomarker research in HELLP; leaves open causal role and clinical utility pending prospective studies.
Protein Z (PZ) was found to be associated with pregnancy complications. There are no data implying an association between hemolysis (H), elevated liver enzymes (EL), and low platelet counts (LP) (HELLP) syndrome and changes in plasma levels of PZ. The aim of this study is to investigate whether HELLP syndrome is associated with plasma concentrations of PZ. Protein Z levels in 29 women with HELLP syndrome were compared with 29 healthy, nulliparous and 25 normal pregnant women. The median PZ levels in patients with HELLP syndrome were found to be significantly lower than those of pregnant women. No significant difference was found between HELLP and healthy groups. Protein Z levels correlated with platelet counts, lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) levels in patients with HELLP syndrome. Median PZ level was higher in partial HELLP than in complete HELLP. We calculated 1330 ng/mL as a cutoff value for PZ level to discriminate HELLP syndrome from normal pregnancy. Low PZ levels are associated with the pathobiology of HELLP syndrome.
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Kaygusuz et al. (2010) conducted a case-control in HELLP syndrome (n=83). Protein Z levels vs. Normal pregnant women and healthy nulliparous women was evaluated on Plasma Protein Z levels. Plasma Protein Z levels were significantly lower in women with HELLP syndrome compared to normal pregnant women, with a cutoff of 1330 ng/mL discriminating HELLP from normal pregnancy.
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