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A critical test: We have used Red/ET recombination in a heterologous expression vector to site-specifically modify the pathway to the myxobacterial metabolite myxothiazol. Our mutagenesis results strengthen an existing model for interpolypeptide “docking” during biosynthesis of such hybrid polyketide–nonribosomal peptide natural products.
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Li et al. (2010) studied this question.
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