Six diabetic patients with either a nephrectomy or a congenitally single kidney, and who later developed diabetic nephropathy, are described. They represent about 3% of our diabetic population with nephropathy, and are the only patients in our clinic population known to have single kidneys. A reduced renal mass may augment the renal glomerular hyperfiltration associated with diabetes mellitus and increase the risk of later developing nephropathy.
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Sampson et al. (1990) studied this question.
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