Key result
Two solid organ transplant recipients develop high-grade angiosarcoma following a lymphoproliferative disorder.
Why the study?
Posttransplant malignancies are common after solid organ transplants, but angiosarcoma is rare and its association with lymphoproliferative disorders is not well described.
Case Report (n=2)
No
Highlights a rare occurrence of concomitant high-grade angiosarcoma and lymphoproliferative disorder in solid organ transplant recipients.
Answers are grounded in this paper and cite their sources.
Raises possibility of angiosarcoma after post-transplant LPD; leaves open whether monoclonal IgH rearrangement marks shared risk or progression.
An increased risk of posttransplant malignancy has been consistently reported following various solid organ transplants. The malignancies most commonly encountered are non-melanoma skin cancers, carcinomas of lung or breast and posttransplant lymphoproliferative disorders. Angiosarcoma, an uncommon vascular mesenchymal neoplasm, is rare in the posttransplant setting. This report describes two patients who developed high-grade angiosarcoma following a solid organ transplant. Notably, in both patients, the diagnosis of angiosarcoma was preceded by diagnosis of a lymphoproliferative disorder with monoclonal immunoglobulin heavy chain rearrangement.
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Baer et al. (2014) conducted a case report in Concomitant angiosarcoma and posttransplant lymphoproliferative disorder (n=2). Solid organ transplantation and immunosuppression was evaluated. Two solid organ transplant recipients developed high-grade angiosarcoma that was preceded by a diagnosis of a lymphoproliferative disorder with monoclonal immunoglobulin heavy chain rearrangement.
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