Narrative review highlights emerging viral infection models in Caenorhabditis elegans, suggesting new opportunities to study virus-host interplay in genetically tractable organisms.
Since 1999, Caenorhabditis elegans has been extensively used to study microbe-host interactions due to its simple culture, genetic tractability, and susceptibility to numerous bacterial and fungal pathogens. In contrast, virus studies have been hampered by a lack of convenient virus infection models in nematodes. The recent discovery of a natural viral pathogen of C. elegans and development of diverse artificial infection models are providing new opportunities to explore virus-host interplay in this powerful model organism.
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Don B. Gammon (2017) studied this question.
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