Bioinformatic analysis reveals a CD8+ T cell-related gene model predicts survival in clear cell renal cell carcinoma, highlighting its potential for targeted immunotherapy and prognosis.
Key Points
To establish and validate a novel prognostic risk model for clear cell renal cell carcinoma using CD8+ T cell infiltration-related genes.
Screened CD8+ T cell infiltration-related genes using least absolute shrinkage and selection operator (LASSO) regression to construct a prognostic risk signature.
Evaluated differential gene expression, correlated model genes with chemotherapeutic sensitivity, and analyzed relationships between risk scores and immune checkpoint markers.
The constructed gene signature served as an independent prognostic factor with an AUC of 0.705, where higher risk scores correlated with worse survival.
Model genes CD7 and TTC24 demonstrated strong correlations with nelarabine sensitivity, while PDCD1 and RTP5 correlated strongly with bendamustine response (r > 0.6, p < 0.001).