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September 15, 2026BJU InternationalOpen Access

Prospective randomised double‐blind trial: holmium laser lithotripsy with vs without Moses™ 2.0

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Authors

KMKimberly A. MaciolekVanderbilt University Medical CenterNNNaren NimmagaddaJohns Hopkins UniversityALAaron LeeVanderbilt University Medical Center

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Overview

Randomized double-blind trial demonstrates reduced surgeon workload without differences in operative time for renal stones, suggesting ergonomic benefits of Moses 2.0 technology.

Key Points

  • To evaluate whether Moses 2.0 pulse technology during holmium laser lithotripsy reduces operative time, surgeon workload, and stone retropulsion for 8–20 mm renal stones.
  • Conducted a multicenter, randomized, double-blind clinical trial enrolling 153 patients (79 Standard laser, 74 Moses 2.0) stratified by stone size.
  • Evaluated primary outcomes of total operative time and surgeon workload via the NASA-Task Load Index (NASA-TLX), alongside secondary outcomes of retropulsion via blinded video review and clinical success, using linear regression modeling.
  • Total operative time showed no statistically significant difference between the standard and Moses 2.0 groups (P = 0.73), and stone retropulsion rates were also similar (P = 0.13).
  • Moses 2.0 was associated with significantly reduced effort, frustration, mental, physical, and temporal workload, as well as higher rated overall surgeon performance.
  • Complication rates (13% in Standard vs 10% in Moses 2.0) and stone-free rates (51% in Standard vs 55% in Moses 2.0) did not differ significantly between treatment arms.

Cite This Study

Maciolek et al. (2026) studied this question.

synapsesocial.com/papers/6aa9134b9013453be30a11cbhttps://doi.org/10.1111/bju.70446
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