What does this research mean for the field?

The admission FIB-4 index is independently associated with three-year mortality in severe COVID-19 patients, outperforming APRI and chest CT severity scores, although its prognostic value largely overlaps with age. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine the long-term prognostic value of liver fibrosis markers (FIB-4 and APRI) compared to chest CT severity scores for predicting three-year mortality in patients hospitalized with severe COVID-19 pneumonia.

September 15, 2026COVIDOpen Access

FIB-4 Index Discriminates Long-Term Mortality Better than Chest CT Severity Scores in Severe COVID-19

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FBFurkan Bölen AAAyşe Paralı Ak MKMerve Kapçık

Discussion

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Overview

Retrospective cohort study reveals superior mortality prediction with FIB-4 over chest CT in severe COVID-19, indicating its role as a composite admission risk marker.

Key Points

To determine the long-term prognostic value of liver fibrosis markers (FIB-4 and APRI) compared to chest CT severity scores for predicting three-year mortality in patients hospitalized with severe COVID-19 pneumonia.
Retrospective single-center study evaluating 101 adults hospitalized with severe COVID-19 pneumonia followed for three years.
FIB-4, APRI, and chest CT severity scores were calculated from admission data.
Discriminative ability was analyzed via AUC with DeLong tests, and multivariable nested logistic regression assessed prognostic utility beyond age and inflammatory markers.
Total mortality was 56.4% (57/101 patients; 39 in-hospital and 18 post-discharge), with admission FIB-4 significantly higher in non-survivors (median 3.0 vs. 1.5; p < 0.001).
Admission FIB-4 demonstrated superior prognostic discrimination for mortality compared to APRI (AUC 0.746 vs. 0.595; p = 0.002) and chest CT severity score (AUC 0.746 vs. 0.490; p = 0.001), performing similarly to age alone (AUC 0.756; p = 0.870).
Log-FIB-4 predicted mortality after adjusting for age (OR 2.04, 95% CI 1.10–3.76), while a threshold of FIB-4 > 2.44 had an age-adjusted OR of 5.90 (95% CI 2.20–15.83), though it was not associated with death among patients who survived to hospital discharge.

Cite This Study

Bölen et al. (2026) studied this question.

synapsesocial.com/papers/6aa9136e9013453be30a1533 https://doi.org/10.3390/covid6090163

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September 15, 2026COVIDOpen Access

FIB-4 Index Discriminates Long-Term Mortality Better than Chest CT Severity Scores in Severe COVID-19

View Full Paper

Ask AI

Bookmark

Authors

FBFurkan Bölen AAAyşe Paralı Ak MKMerve Kapçık

Discussion

Member takes

Overview

Retrospective cohort study reveals superior mortality prediction with FIB-4 over chest CT in severe COVID-19, indicating its role as a composite admission risk marker.

Key Points

To determine the long-term prognostic value of liver fibrosis markers (FIB-4 and APRI) compared to chest CT severity scores for predicting three-year mortality in patients hospitalized with severe COVID-19 pneumonia.
Retrospective single-center study evaluating 101 adults hospitalized with severe COVID-19 pneumonia followed for three years.
FIB-4, APRI, and chest CT severity scores were calculated from admission data.
Discriminative ability was analyzed via AUC with DeLong tests, and multivariable nested logistic regression assessed prognostic utility beyond age and inflammatory markers.
Total mortality was 56.4% (57/101 patients; 39 in-hospital and 18 post-discharge), with admission FIB-4 significantly higher in non-survivors (median 3.0 vs. 1.5; p < 0.001).
Admission FIB-4 demonstrated superior prognostic discrimination for mortality compared to APRI (AUC 0.746 vs. 0.595; p = 0.002) and chest CT severity score (AUC 0.746 vs. 0.490; p = 0.001), performing similarly to age alone (AUC 0.756; p = 0.870).
Log-FIB-4 predicted mortality after adjusting for age (OR 2.04, 95% CI 1.10–3.76), while a threshold of FIB-4 > 2.44 had an age-adjusted OR of 5.90 (95% CI 2.20–15.83), though it was not associated with death among patients who survived to hospital discharge.

Cite This Study

Bölen et al. (2026) studied this question.

synapsesocial.com/papers/6aa9136e9013453be30a1533 https://doi.org/10.3390/covid6090163

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