Key result
Combined lipid parameters like non-HDL-C are linked to target organ damage, unlike individual lipids.
Why the study?
Are combined lipid parameters (such as non-HDL-C and TC/HDL) better associated with target organ damage than individual lipid parameters in an elderly community cohort?
Cohort (n=1,599)
No
Are combined lipid parameters (such as non-HDL-C and TC/HDL) better associated with target organ damage than individual lipid parameters in an elderly community cohort?
Non-HDL-C and TC/HDL ratio are better associated with target organ damage than individual lipid parameters in elderly individuals, supporting their use as targets in lipid-lowering therapy.
May inform combined lipid assessment in elderly cohorts; hypothesis-generating and leaves open whether targeting improves outcomes.
BACKGROUND: Recommendations of non-HDL amplification varied from different guidelines. We aim to test the relationships between various lipid parameters and target organ damage (TOD) including aortic stiffness, peripheral arterial disease and chronic kidney disease in a community-based elderly cohort. METHODS: 1599 (aged 71.4 ± 6.1 years) participants were recruited. Eight lipid parameters, including total cholesterol (TC), triglycerides (TG), LDL-C, HDL-C, non-HDL-C, TC/HDL ratio, TG/HDL ratio and LDL/HDL ratio, together with other plasma biomarkers like creatinine were measured. Pulse wave velocity (PWV) was measured by the SphygmoCor device, and ankle-brachial index (ABI) was assessed by Omron VP-1000 device. RESULTS: Four individual lipid parameters (TC, TG, LDL-C and HDL-C) significantly correlated with most, but not all, TOD indices. Meanwhile, 4 combined lipid parameters, namely non-HDL-C, TC/HDL, TG/HDL and LCL/HDL, significantly correlated with all TOD (P ≤ 0.033). In multiple linear regression analyses, 4 combined lipid parameters also significantly associated with TOD (P ≤ 0.027), while none of individual lipid parameters significantly associated with all TOD indices. In multiple logistic regression analyses, only non-HDLC and TC/HDL significantly associated with TOD (P ≤ 0.039), and other lipid parameters did not significantly associate with TOD. CONCLUSION: In an elderly community sample, non-HDLC and TC/HDLC were better associated with TOD than other lipid parameters. This finding should be considered in future clinical lipid-lowing therapy. TRIAL REGISTRATION: This trial was retrospectively registered in ClinicalTrials.gov (No. NCT02368938 , registered on 15 Feb 2015).
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Chi et al. (2018) conducted a cohort in Target organ damage (aortic stiffness, peripheral arterial disease, chronic kidney disease) (n=1,599). Combined lipid parameters (non-HDL-C and TC/HDL ratio) vs. Individual lipid parameters (TC, TG, LDL-C, HDL-C) was evaluated on Association with target organ damage (arterial stiffness, peripheral arterial disease, and chronic kidney disease) (p=≤0.039). In a community-dwelling elderly cohort, combined lipid parameters including non-HDL-C and TC/HDL ratio were significantly associated with all measured target organ damage indices, whereas individual lipid parameters were not.
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