Why the study?
Little was known regarding the relationship between arterial stiffness and cardiovascular target organ damage in the general population.
Are measurements of arterial stiffness associated with cardiovascular target organ damage in a general population without prior cardiovascular events?
Are measurements of arterial stiffness associated with cardiovascular target organ damage in a general population without prior cardiovascular events?
Arterial stiffness measurements correlate with target organ damage, but this association is driven by underlying cardiovascular risk factors rather than being an independent predictor.
Arterial stiffness measures should not independently guide TOD assessment; leaves open their incremental prognostic value in prospective cohorts.
Introduction Little is known about the relationship between arterial stiffness and cardiovascular target organ damage (TOD) in the general population. The aim was to analyse the relationship between different measurements of arterial stiffness and TOD, in a general Spanish population without a history of cardiovascular event.Materials and methods Transversal descriptive study. Through stratified random sampling, a total of 501 individuals were included. Carotid-femoral pulse wave velocity (cf-PWV) was measured using a SphygmoCor System®, the cardio-ankle vascular index (CAVI) was determined with aVasera VS-1500® and brachial-ankle pulse wave velocity (ba-PWV)was calculated through a validated equation.Results The average age was 55.84 ± 14.26.The percentage of vascular TOD, left ventricular hypertrophy (LVH) and renal TOD was higher in men (p < .001). A positive correlation was obtained between carotid intima-media thickness (c-IMT) and the measurements of vascular function. In the model 1 of the logistic regression analysis, cf-PWV was associated with vascular TOD (OR = 1.15, p = .040), ba-PWV was associated with vascular TOD (OR = 1.20, p = .010) and LVH (OR = 1.12, p = .047).Conclusions The different measurements of arterial stiffness are highly associated with each other. Moreover, cf-PWV and ba-PWV were associated with vascular TOD, and ba-PWV with LVH, although they disappear when adjusting for cardiovascular risk factors.Key MessagesThere is a strong correlation between the different measurements of vascular structure and function.Carotid-femoral and brachial-ankle pulse wave velocity were positively associated with vascular target organ damage, the latter was also positively associated with left ventricular hypertrophy.This associations disappear when adjusting for cardiovascular risk factors.
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Alonso‐Domínguez et al. (2021) studied this question.
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