Association of Blood Pressure–Related Increase in Vascular Stiffness on Other Measures of Target Organ Damage in Youth
Key result
Higher arterial stiffness was significantly associated with elevated blood pressure and target organ damage in youth after controlling for blood pressure.
Why the study?
Hypertension-related increased arterial stiffness predicts target organ damage, but whether BP-related arterial stiffness is present in youth with elevated BP and associated with target organ damage remained to be evaluated.
Is blood pressure-related increased arterial stiffness associated with target organ damage in youth?
Population
Youth stratified into low- (n=155), mid- (n=88), and high-risk (n=139) systolic BP categories
Comparison
Low- vs mid- vs high-risk systolic BP categories
Design
Cross-sectional study
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for arterial stiffness assessment in youth hypertension; prospective studies needed before clinical adoption.
Study Design
Type
Cross-Sectional (n=382)
Structured PICO
Is blood pressure-related increased arterial stiffness associated with target organ damage in youth?
P
Population
382 youth stratified by systolic blood pressure into low, mid, and high-risk categories to evaluate the association between arterial stiffness and target organ damage.
C
Comparator
Low-risk BP category (systolic BP <75th percentile)
O
Outcome
Arterial stiffness (carotid-femoral pulse wave velocity and aortic stiffness) and target organ damage (left ventricular mass index, left ventricular systolic and diastolic function, and urine albumin/creatinine)surrogate
Higher arterial stiffness is associated with elevated blood pressure and target organ damage in youth, highlighting the importance of early primary prevention of cardiovascular disease.
Cite This Study
Haley et al. (2022) conducted a cross-sectional in Elevated blood pressure (n=382). Elevated blood pressure and arterial stiffness vs. Low-risk blood pressure (<75th percentile) was evaluated on Target organ damage (systolic and diastolic cardiac function and urine albumin/creatinine ratio). Higher arterial stiffness was significantly associated with elevated blood pressure and target organ damage in youth after controlling for blood pressure.