In healthy adolescents, neck circumference had a stronger, blood pressure-independent association with carotid stiffness compared to aortic stiffness (Fisher z-to-R 2.07, P=0.04).
Cross-Sectional (n=322)
No
Is the association between adiposity and arterial stiffness in healthy adolescents mediated by blood pressure or independent of it?
In healthy adolescents, fat accumulation is associated with arterial stiffness, with carotid stiffness showing a stronger, blood pressure-independent association with adipose tissue excess compared to aortic stiffness.
Effect estimate: Fisher z-to-R 2.07
p-value: p=0.04
OBJECTIVE: Children and adolescents with adiposity excess are at increased risk of future cardiovascular (CV) disease. Fat accumulation promotes the development of elevated blood pressure (BP) and arterial stiffness, two main determinants of CV risk which are strongly inter-related. We aimed at investigating whether the association between overweight and arterial stiffness, taken at different arterial segments, is mediated by increased BP or is BP-independent. METHODS: Three hundred and twenty-two Italian healthy adolescents (mean age 16.9±1.4 years, 12% with overweight) attending the "G. Donatelli" High School in Terni, Italy, underwent measurement of arterial stiffness by arterial tonometry (aortic stiffness) and semiautomatical detection of pressure-volume ratio of the common carotid (carotid stiffness). The mediator effect of BP was tested for each anthropometric or biochemical measure of fat excess related to arterial stiffness. RESULTS: Both carotid and aortic stiffness showed positive correlations with body mass index, waist, hip, and neck circumferences (NC). Only carotid stiffness, but not aortic stiffness, was associated with serum markers of fat accumulation and metabolic impairment such as insulin, homeostatic model of insulin resistance (HOMA-IR), serum gamma-glutamyl transferase (sGGT) and uric acid. The association with NC was stronger for carotid than for aortic stiffness (Fisher z -to- R 2.07, P = 0.04), and independent from BP. CONCLUSIONS: In healthy adolescents, fat accumulation is associated with arterial stiffness. The degree of this association differs by arterial segments, since carotid stiffness is more strongly associated to adipose tissue excess than aortic stiffness and shows a BP-independent association with NC whereas aortic stiffness does not.
Pucci et al. (Tue,) conducted a cross-sectional in Healthy adolescents (n=322). Adiposity and fat accumulation was evaluated on Association between overweight/fat accumulation and arterial stiffness (carotid and aortic) (Fisher z-to-R 2.07, p=0.04). In healthy adolescents, neck circumference had a stronger, blood pressure-independent association with carotid stiffness compared to aortic stiffness (Fisher z-to-R 2.07, P=0.04).
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