Key result
Higher BMI and childhood PWV independently predict increased arterial stiffness in early adolescence.
Why the study?
Carotid-femoral PWV increases with age and may be accelerated by cardiometabolic risk factors, but its progression from prepubertal age to early adolescence and determinants remain to be clarified.
Population
118 participants from the Generation XXI cohort assessed at ages 8-9 and 13-14 years
Comparison
Overweight/obese adolescents vs non-overweight peers
Design
Longitudinal cohort study
Authors
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Adolescent arterial stiffness was associated with childhood PWV and BMI; hypothesis-generating and should not yet change practice.
Cohort (n=118)
No
Effect estimate: β = 0.33
p-value: p=<0.001
Arterial stiffness in early adolescence is independently predicted by childhood arterial stiffness and concurrent adiposity, highlighting the importance of early weight management.
Ventura et al. (2026) conducted a cohort in Arterial stiffness and adiposity (n=118). Overweight/obesity (BMI z-score) vs. Non-overweight peers was evaluated on Carotid-femoral pulse wave velocity (PWV) at 13-14 years (β = 0.33, p=<0.001). Higher BMI z-score at 13-14 years (β = 0.33; p < 0.001) and childhood PWV independently predicted increased arterial stiffness in early adolescence.
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