Key result
Whole genome sequencing reveals continued evolution of a Hungarian G3P[8] rotavirus strain via reassortment.
Why the study?
Novel intergenogroup reassortant G3 rotavirus strains are spreading globally, but evidence of their circulation and evolution in Hungary was lacking.
The study provides evidence of the genomic plasticity and ongoing reassortment of a novel equine-like G3 rotavirus strain in Hungary.
Highlights need for rotavirus genomic surveillance; leaves open impact on vaccine effectiveness against evolving strains.
Novel, intergenogroup reassortant G3 rotavirus strains are spreading in at least three continents: Asia, Australia, and Europe. The present study provides evidence that a closely related G3P[8] strain circulated in Hungary during 2015. Whole genome sequencing and phylogenetic analysis showed that the identified strain continues to evolve by reassortment. This observation demonstrates the genomic plasticity of the novel strain, which is thought to be a prerequisite of the success of emerging rotavirus genotypes.
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Dóró et al. (2016) studied Rotavirus infection. Equine-like G3 rotavirus strain was evaluated on Genomic evolution and reassortment. Whole genome sequencing and phylogenetic analysis of a closely related G3P[8] rotavirus strain in Hungary demonstrated its continued evolution by reassortment and genomic plasticity.
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