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September 15, 2026AI and EthicsOpen Access

Co-design of a trustworthy AI-based prognostic tool for predicting patient outcome in acute stroke

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Authors

EHElizabeth HofvenschioeldAHAdam HilbertCBCathrine K. T. Bui

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Overview

Descriptive case study reveals an ethical co-design framework for AI in acute stroke, demonstrating how trustworthy principles translate into technical and clinical requirements.

Key Points

  • To implement and evaluate an ethically aligned co-design methodology during the early development phase of an AI-based prognostic tool for acute ischaemic stroke.
  • Conducted a descriptive, process-oriented case study applying the Z-Inspection® framework within the Horizon Europe VALIDATE project.
  • Convened an interdisciplinary panel of ethics experts, AI developers, and clinical stakeholders to systematically analyze ethical, legal, and technical factors.
  • Identified 22 ethical issues, 12 ethical dilemmas, and 18 operational risks inherent to prognostic AI implementation.
  • Formulated 48 actionable requirements across technical, clinical, governance, and organizational domains mapped to European Commission trustworthy AI principles.

Cite This Study

Hofvenschioeld et al. (2026) studied this question.

synapsesocial.com/papers/6aa913909013453be30a1a17https://doi.org/10.1007/s43681-026-01337-3
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