Review demonstrates 2D material field-effect transistors for biomedical diagnostics, highlighting sensitive detection for point-of-care healthcare monitoring.
Key Points
Synthesize recent advances in 2D material field-effect transistor (FET) biosensors based on graphene and transition metal dichalcogenides for biomedical diagnostic applications.
Conducted an extensive review analyzing material properties, device architectures, and operating principles of graphene and TMDC FET biosensors.
Evaluated performance metrics across back-gate, liquid-gate, dual-gate, and extended-gate device structures.
Assessed integration barriers, focusing on CMOS compatibility, environmental stability, and fabrication uniformity.
Graphene demonstrates exceptional carrier mobility and ambipolar transport for ultra-high sensitivity, while TMDCs provide narrow bandgaps and high on/off ratios for low-power operation.
Liquid-gate and extended-gate FET configurations enable real-time, low-voltage biomarker detection in biological fluids for point-of-care diagnostics.
CMOS compatibility, environmental stability, and manufacturing variability represent the primary hurdles to clinical and commercial translation.