Metabolic Syndrome Effects over Heart Tissue: A Histomorphological Glance under the Light of p97/VCP and SVIP

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Metabolic syndrome induces histomorphological alterations and affects the expression levels of p97/VCP and SVIP in rat heart tissue. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Şeyma Kipel; Ayça Bilginoğlu; Makbule Fulya Tutar Selcuk; Hilal Nakkaş

doi:10.19127/bshealthscience.1914438

September 14, 2026Black Sea Journal of Health Science

Metabolic Syndrome Effects over Heart Tissue: A Histomorphological Glance under the Light of p97/VCP and SVIP

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Key Points

Investigate histomorphological alterations and the expression of p97/VCP and SVIP proteins in cardiac tissue using a rat model of metabolic syndrome.
Evaluated structural myocardial changes in rat heart tissues using Hematoxylin-Eosin and Weigert Van Gieson histological staining methods.
Examined protein expression and localization of p97/VCP and SVIP in cardiac tissue via immunohistochemistry.
Demonstrated pathological histomorphological alterations in cardiac tissue architecture induced by metabolic syndrome.
Identified altered expression profiles of the cellular stress regulators p97/VCP and SVIP within affected rat heart tissue.

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Implication

Animal experimental study reveals histomorphological changes and altered p97/VCP and SVIP in rat heart tissue, indicating impaired cardiac protein quality control.

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Kipel et al. (2026) studied this question.

synapsesocial.com/papers/6aa913c79013453be30a1e39 https://doi.org/10.19127/bshealthscience.1914438

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Metabolic Syndrome Effects over Heart Tissue: A Histomorphological Glance under the Light of p97/VCP and SVIP

Key Points

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Implication

Discussion

Cite This Study

Metabolic Syndrome Effects over Heart Tissue: A Histomorphological Glance under the Light of p97/VCP and SVIP

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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