What does this research mean for the field?

Unchecked antimicrobial resistance, driven by human, agricultural, and environmental factors, poses an imminent global catastrophe that requires immediate, coordinated One Health interventions to prevent a return to a pre-antibiotic era. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Synthesize global evidence on the disease burden, biological and environmental drivers, economic consequences, and systemic solutions associated with escalating antimicrobial resistance.

September 15, 2026BiomedicinesOpen Access

Antibiotic Resistance and the Return to a Pre-Antibiotic Era: A Critical Narrative Review of a Global Catastrophe

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Authors

SPShaurya Prakash SSSaloni Saini MBMahima Bharti

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Overview

Narrative review reveals escalating antimicrobial resistance caused 1.27 million direct deaths globally in 2019, highlighting the imminent risk of entering a post-antibiotic era without policy action.

Key Points

Synthesize global evidence on the disease burden, biological and environmental drivers, economic consequences, and systemic solutions associated with escalating antimicrobial resistance.
Synthesized global surveillance and research data from 2000 through early 2026, incorporating Global Research on Antimicrobial Resistance (GRAM) datasets and World Health Organization records.
Evaluated One Health drivers spanning human clinical prescribing, agricultural livestock consumption, and environmental water contamination alongside macroeconomic projection models.
Bacterial resistance caused 1.27 million direct deaths and contributed to 4.95 million total deaths in 2019, with the highest burden concentrated in low- and middle-income countries.
Identified primary systemic drivers, including 70% of global antibiotic consumption occurring in agriculture, 30% inappropriate prescribing in high-income settings, and resistance genes present in 72% of rivers.
Documented near 50% intensive care unit mortality from critical ESKAPE pathogens, with macroeconomic forecasts estimating global annual GDP reductions between 1.1% and 3.8% (up to approximately 5%) by 2050.

Cite This Study

Prakash et al. (2026) studied this question.

synapsesocial.com/papers/6aa913d99013453be30a218a https://doi.org/10.3390/biomedicines14092053

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September 15, 2026BiomedicinesOpen Access

Antibiotic Resistance and the Return to a Pre-Antibiotic Era: A Critical Narrative Review of a Global Catastrophe

View Full Paper

Ask AI

Bookmark

Authors

SPShaurya Prakash SSSaloni Saini MBMahima Bharti

Discussion

Member takes

Overview

Key Points

Synthesize global evidence on the disease burden, biological and environmental drivers, economic consequences, and systemic solutions associated with escalating antimicrobial resistance.
Synthesized global surveillance and research data from 2000 through early 2026, incorporating Global Research on Antimicrobial Resistance (GRAM) datasets and World Health Organization records.
Evaluated One Health drivers spanning human clinical prescribing, agricultural livestock consumption, and environmental water contamination alongside macroeconomic projection models.
Bacterial resistance caused 1.27 million direct deaths and contributed to 4.95 million total deaths in 2019, with the highest burden concentrated in low- and middle-income countries.
Identified primary systemic drivers, including 70% of global antibiotic consumption occurring in agriculture, 30% inappropriate prescribing in high-income settings, and resistance genes present in 72% of rivers.
Documented near 50% intensive care unit mortality from critical ESKAPE pathogens, with macroeconomic forecasts estimating global annual GDP reductions between 1.1% and 3.8% (up to approximately 5%) by 2050.

Cite This Study

Prakash et al. (2026) studied this question.

synapsesocial.com/papers/6aa913d99013453be30a218a https://doi.org/10.3390/biomedicines14092053

View Full Paper

Ask AI

Bookmark