What does this research mean for the field?

A newly synthesized molecularly imprinted polymer (MIP) combined with solid-phase extraction and UV-Vis spectroscopy provides a highly selective, accurate, and precise method for measuring lorazepam concentrations in pharmaceutical formulations. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To synthesize and evaluate a novel molecularly imprinted polymer as a selective sorbent for the solid-phase extraction and quantification of lorazepam in pharmaceutical formulations.

September 15, 2026Canadian Journal of Chemistry

Synthesis of new molecularly imprinted polymers for selective extraction followed by solid phase determination of Lorazepam concentration in a pharmaceutical preparation

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Authors

FAFatima Najim AbedUniversity of Kerbala YAYehya Kamal Al-BayatiUniversity of Baghdad SJSabaa Abd JaberUniversity of Baghdad

Discussion

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Implication

Experimental analytical study demonstrates selective extraction and precise measurement of lorazepam in pharmaceutical formulations, indicating a rapid, cost-effective approach for drug testing.

Key Points

To synthesize and evaluate a novel molecularly imprinted polymer as a selective sorbent for the solid-phase extraction and quantification of lorazepam in pharmaceutical formulations.
Synthesized the polymer via free radical bulk polymerization using lorazepam as the template, isopropylacrylamide as the functional monomer, glycidyl methacrylate as the crosslinker, and benzoyl peroxide as the initiator.
Characterized the synthesized polymer's morphology and structural properties using UV–Vis spectroscopy, Fourier-transform infrared spectroscopy, and scanning electron microscopy.
Systematically optimized solid-phase extraction parameters, including sorbent mass, sample pH, sample volume, flow rate, and elution conditions, coupled with UV–Vis detection.
The extraction method showed strong linearity over the tested range with an R² of 0.9990, achieving a limit of detection of 0.92 µmol L⁻¹ and a limit of quantification of 3.10 µmol L⁻¹.
Application to pharmaceutical preparations demonstrated high accuracy and precision, yielding recoveries of 98.0% to 104.0% with relative standard deviations below 3.5%.

Cite This Study

Abed et al. (2026) studied this question.

synapsesocial.com/papers/6aa913e49013453be30a22f3 https://doi.org/10.1139/cjc-2026-0142

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Implication

Experimental analytical study demonstrates selective extraction and precise measurement of lorazepam in pharmaceutical formulations, indicating a rapid, cost-effective approach for drug testing.