Key result
ApoE/ApoB ratio cut-off of 0.09 identifies type III hyperlipoproteinemia with high diagnostic sensitivity.
Why the study?
A reliable screening marker for identifying patients with type III hyperlipoproteinaemia in the clinical laboratory was needed.
Does the apolipoprotein E to apolipoprotein B ratio accurately identify patients with type III hyperlipoproteinaemia?
Case-Control (n=88)
Yes
Does the apolipoprotein E to apolipoprotein B ratio accurately identify patients with type III hyperlipoproteinaemia?
The apolipoprotein E to apolipoprotein B ratio is a highly sensitive and specific screening tool for identifying type III hyperlipoproteinaemia.
May support apoE/apoB ratio screening for type III hyperlipoproteinaemia; leaves open prospective validation before clinical adoption.
Apolipoproteins B and E were determined in 40 patients with type III hyperlipoproteinaemia (familial dysbetalipoproteinaemia) and in 48 patients with other types of hyperlipoproteinaemia matched for cholesterol and triacylglycerols. In type III patients, apolipoprotein E was increased and apolipoprotein B was lower than in other types of hyperlipoproteinaemia. The apolipoprotein E to apolipoprotein B ratio almost completely discriminated between type III and other types of hyperlipoproteinaemia. Assuming a cut-off value of 0.09 for the apolipoprotein E to apolipoprotein B ratio, diagnostic sensitivity was 95% and specificity was 88%. It is concluded that the apolipoprotein E to apolipoprotein B ratio represents the first-line screening quantity of choice for the identification of patients with type III hyperlipoproteinaemia in the clinical laboratory.
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März et al. (1993) conducted a case-control in Type III hyperlipoproteinaemia (n=88). Apolipoprotein E to B ratio vs. Other types of hyperlipoproteinaemia was evaluated on Apolipoprotein E to apolipoprotein B ratio. An apolipoprotein E to apolipoprotein B ratio cut-off of 0.09 identified type III hyperlipoproteinaemia with a diagnostic sensitivity of 95% and specificity of 88%.
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