In Vitro Biosynthesis of the Prepeptide of Type‐III Lantibiotic Labyrinthopeptin A2 Including Formation of a CC Bond as a Post‐Translational Modification

This is the authors' abstract. We don't add key points for this paper.

A way through the labyrinth: LabKC is an enzyme encoded in the biosynthesis gene cluster (lab gene cluster) of the labyrinthopeptin producer Actinomadura namibiensis. Some of its genes are homologous with those in other actinomycetes strains, for example, the model organism Streptomyces coelicolor. The functional assignment of LabKC as a kinase–cyclase suggests the formation of a new post-translational modification by a consecutive double Michael addition (see scheme; Dha=α,β-dehydroalanine).