Approximately 1 in 5 US adults have at least one episode of major depression in their lifetime. Of those who do, the majority will relapse over the long term and many will have psychosocial disabilities and reduced functioning. Over the past century, a range of medications have been developed to treat depression, although some effective medications have been superseded by newer treatments with an improved safety and tolerability profile. A reconsideration of some older medications is warranted until agents with truly novel mechanisms of action and good safety and tolerability profiles are available. (J Clin Psychiatry 2012;73:e29) From the Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston. doi:10.4088/JCP.11096tx3c This CME activity is expired. For more CME activities, visit cme.psychiatrist.com. Find more articles on this and other psychiatry and CNS topics: The Journal of Clinical Psychiatry The Primary Care Companion for CNS Disorders
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Robert M. A. Hirschfeld (2012) studied this question.