Key result
Early elderly hypertensive patients show no difference in urinary 8-OHdG levels versus healthy controls.
Why the study?
Oxidative stress from reactive oxygen species underlies vascular stiffening in hypertension, prompting evaluation of urinary 8-hydroxy-deoxyguanosine as an oxidative stress biomarker.
Does the level of urinary 8-OHdG differ between early elderly hypertensive patients and healthy controls?
Cross-Sectional (n=80)
Yes
Does the level of urinary 8-OHdG differ between early elderly hypertensive patients and healthy controls?
Absolute Event Rate: 1.871% vs 1.743%
p-value: p=0.053
Urinary 8-OHdG levels do not significantly differ between early elderly hypertensive patients and healthy controls, suggesting it may not be a distinct biomarker for oxidative damage in this specific population.
Does not support urinary 8-OHdG as a distinguishing biomarker in early elderly hypertension; leaves open its utility in other cohorts or designs.
According to JNC VII, patients with hypertension are patients who clinically have systolic and diastolic blood pressure ≥140 mmHg and ≥90 mmHg, respectively. The aging processes in hypertension are stiffening of the blood vessels and decreasing arterial flexibility. The underlying pathomechanism is oxidative stress due to reactive oxygen species (ROS) elevation. 8-Hydroxy-Deoxyguanosine (8-OHdG) is an oxidized product of DNA repair as a kind of oxidative stress biomarker. This study aimed to analyze urinary 8-OHdG in hypertensive patients and healthy control aged 46-55 years old by involveing 80 participants. Questionnaires and medical records were collected to obtain relevant clinical data. The level of 8-OHdG is measured by the Enzyme-Linked Immunosorbent Assay (ELISA). The results showed that there is no difference in the average urinary level of urinary 8-OHdG of hypertensive patients (1.871 ± 0.689 ng/mL) with the healthy controls (1.743 ± 0.364 ng/mL).
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Sumarlie et al. (2022) conducted a cross-sectional in Hypertension (n=80). Hypertension vs. Healthy controls was evaluated on Urinary 8-OHdG level (ng/mL) (p=0.053). There was no significant difference in average urinary 8-OHdG levels between early elderly hypertensive patients and healthy controls (1.871 vs 1.743 ng/mL, p=0.053).
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