Key result
PCOS in non-obese young women is linked to greater arterial stiffness versus controls.
Why the study?
While metabolic abnormalities in polycystic ovarian syndrome (PCOS) are documented, few studies have evaluated cardiovascular risk in these women.
Does polycystic ovarian syndrome increase arterial stiffness measured by cardio-ankle vascular index in non-obese young women?
Case-Control (n=160)
Does polycystic ovarian syndrome increase arterial stiffness measured by cardio-ankle vascular index in non-obese young women?
Absolute Event Rate: 5.78% vs 5.28%
p-value: p=<0.001
Non-obese young women with PCOS exhibit increased arterial stiffness, which is independently associated with androgen excess, highlighting a potential early marker for cardiovascular risk.
PCOS may associate with higher arterial stiffness by CAVI; leaves open its value for cardiovascular risk stratification.
AIM: The association of metabolic abnormalities and polycystic ovarian syndrome (PCOS) has been documented, but few studies have focused on cardiovascular risk in these women. The aim of this study was to compare arterial stiffness by using the cardio-ankle vascular index (CAVI) in PCOS women with controls, and to evaluate whether any clinical or laboratory variables had independent associations with it. METHODS: A group of 160 women, matched for age and body mass index were recruited. Diagnosis of PCOS was made according to the Rotterdam criteria. Arterial stiffness using CAVI was evaluated in non-obese young woman, with and without PCOS. RESULTS: In the PCOS group (n = 80), 60 cases (75%) had findings of hyperandrogenism, 59 (73.8%) had ovulatory dysfunction, and 70 (87.5%) had an ultrasonographic appearance of polycystic ovaries. Women with PCOS had significantly higher mean CAVI values when compared to subjects without PCOS (5.78 ± 0.64 vs 5.28 ± 0.77, P < 0.001). Multiple regression analysis revealed that androgen excess was associated with increased arterial stiffness, independent of ovulatory dysfunction, polycystic ovaries, body mass index and age. CONCLUSION: This data suggests that vascular compliance is decreased in young women with PCOS. Androgen excess is independently associated with increased arterial stiffness.
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Kılıç et al. (2020) conducted a case-control in Polycystic ovarian syndrome (n=160). Polycystic ovarian syndrome vs. Women without PCOS was evaluated on Arterial stiffness measured by cardio-ankle vascular index (CAVI) (p=<0.001). Polycystic ovarian syndrome in non-obese young women was associated with significantly greater arterial stiffness compared to controls (mean CAVI 5.78 vs 5.28; P<0.001).
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