Key result
Elevated admission Dkk-1 predicts ~37% higher 12-month risk of major events in MI patients.
Why the study?
There was no evidence regarding the prognostic significance of Dkk-1 for ischemic cardiovascular and bleeding events in patients with MI.
Does plasma Dkk-1 level at admission predict cardiovascular and major bleeding outcomes in patients with acute myocardial infarction?
Observational (n=1,364)
Yes
Does plasma Dkk-1 level at admission predict cardiovascular and major bleeding outcomes in patients with acute myocardial infarction?
Hazard Ratio: 1.37 (95% CI 1.13–1.66)
p-value: p=0.001
Plasma Dkk-1 level at admission is a novel prognostic biomarker for predicting 12-month cardiovascular events and major bleeding in patients with acute myocardial infarction.
Admission Dkk-1 may stratify post-MI ischemic and bleeding risk; hypothesis-generating and requires validation before clinical use.
There has been no evidence about the prognostic significance of Dkk-1 (dickkopf-1) for ischemic cardiovascular and bleeding events in patients with myocardial infarction (MI). We aim to evaluate the prognostic effect of Dkk-1 at admission on 12-month risk of cardiovascular and bleeding outcomes in MI. Here we measured plasma Dkk-1 level centrally in 1364 MI patients from BIPass (BIomarker-based Prognostic Assessment for patients with Stable angina and acute coronary Syndromes) study. Dkk-1 was significantly associated with the increased risk of the composite of cardiac death, MI, and ischemic stroke (HR 1.37, 95% CI: 1.13 -1.66, p = 0.001), and major bleeding (HR 1.81, 95% CI:1.13 - 2.90, p = 0.013) after adjusting for clinical risk factors and prognostic biomarkers (hs-cTnT, NT-proBNP, and cystatin C). We first report that Dkk-1 at admission could predict cardiovascular events and major bleeding during 12-month follow-up after MI.Trial registration: clinicaltrials.gov Identifier: NCT04044066.
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Jiali et al. (2022) conducted an observational in Acute myocardial infarction (n=1,364). Dkk-1 (Dickkopf-1) level at admission vs. Lower levels of Dkk-1 was evaluated on Composite of cardiac death, recurrent spontaneous MI, and ischemic stroke (HR 1.37, 95% CI 1.13-1.66, p=0.001). Elevated plasma Dkk-1 levels at admission independently predicted an increased 12-month risk of the composite of cardiac death, myocardial infarction, and ischemic stroke (HR 1.37) in patients with MI.
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