Key result
Simulations show cell-cell interactions and passive tissue structure strongly modulate conduction velocity and repolarization dispersion.
Why the study?
The role of cell-cell interactions and tissue structure in determining action potential propagation and repolarization properties in cardiac tissue was not fully characterized.
Computer simulations demonstrate that electrotonic cell-cell interactions and tissue structure significantly influence cardiac action potential propagation and repolarization dispersion.
Simulations challenge isolated-cell models; leaves open translation to human arrhythmia mechanisms pending intact-heart validation.
This article characterizes through computer simulations, the role of cell-cell interactions and of tissue structure in determining properties of action potential propagation and repolarization in cardiac tissue. The results demonstrate strong interactions between membrane excitatory processes and electrical loading by the passive tissue structure. These interactions modulate the ionic mechanism of conduction and influence conduction velocity and robustness. Cell-cell interactions also have a strong effect on the dispersion of repolarization in cardiac tissue.
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Yoram Rudy (2005) studied Cardiac tissue electrophysiology. Computer simulations of cell-cell interactions and tissue structure was evaluated on Action potential propagation and repolarization. Computer simulations demonstrated that cell-cell interactions and passive tissue structure strongly modulate the ionic mechanism of conduction, conduction velocity, and dispersion of repolarization.
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