Study on the preparation of bovine milk exosomes and the stability of lyophilized powder

This is the authors' abstract. We don't add key points for this paper.

Bovune milk exosomes (MK-exo) have bioactive effects on the health of consumers and can also serve as excellent drug delivery vehicles. However, long-term preservation and transportation remain major challenges at present. In this report, high-quality MK-exo are prepared on a large scale. We then developed a lyophilization method belonging to MK-exo, and performed acceleration and long-term stability experiments on the lyophilized MK-exo to evaluate the effect of lyophilization. The results showed that the lyophilized MK-exo can be stored at room temperature for at least 3 months and 2-8°C℃ for 15 months. These findings provide data support for further understanding of the properties and applications of MK-exo.