Key result
Review outlines the pathogenesis, measurement, and clinical impact of coronary endothelial dysfunction in atherosclerosis.
Why the study?
Endothelial dysfunction plays a substantial role in atherosclerosis and vascular disease pathogenesis, and understanding its measurement techniques and clinical implications is needed.
This review summarizes the pathogenesis, measurement techniques, and clinical implications of coronary endothelial dysfunction.
Endothelial dysfunction assessment may inform atherosclerosis management; leaves open standardization of measurement techniques for clinical adoption.
Endothelial dysfunction (ED) has a substantial role in the pathogenesis of atherosclerosis and other vascular diseases. Multiple risk factors, including smoking, hyperlipiadaemia and diabetes, can have associated ED, which is correlated with cardiac events. Measurement of coronary artery endothelial function requires the use of invasive techniques to assess both epicardial coronary artery and microvascular beds. Peripheral vascular techniques and endothelial biomarkers can be used to indirectly assess coronary ED. In this review of coronary artery ED, we discuss the current state of the field, the techniques used to measure ED and its clinical implications.
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Bockus et al. (2022) conducted a review in Coronary endothelial dysfunction. This review discusses the pathogenesis, measurement techniques, and clinical implications of coronary endothelial dysfunction in atherosclerosis and vascular diseases.
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