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December 26, 2012Cancer DiscoveryOpen Access

Biallelic Deleterious BRCA1 Mutations in a Woman with Early-Onset Ovarian Cancer

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Authors

SDSusan M. DomchekThe Wistar InstituteJTJiang-bo TangMayo ClinicJSJill E. StopferDana-Farber Cancer Institute

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Domchek et al. (2012) studied this question.

synapsesocial.com/papers/6aa9217665c13be784461da0https://doi.org/10.1158/2159-8290.cd-12-0421
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Breast and Ovarian Cancer Risks Due to Inherited Mutations in <i>BRCA1</i> and <i>BRCA2</i>2003 · 2,248 citations
  2. 2Biallelic Inactivation of <i>BRCA2</i> in Fanconi Anemia2002 · 1,151 citations
  3. 3BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity2011 · 249 citations
  4. 4Acute Chemotherapy–Related Toxicity Is Not Increased in <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers Treated for Breast Cancer in the United Kingdom2006 · 37 citations
  5. 5Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from <i>BRCA</i> Mutation Carriers2009 · 3,677 citations