Key result
Pan-caspase inhibition reduces infarct volume and improves neurological deficits in female but not male mice.
Why the study?
Experimental data suggest ischemia-induced cell death pathways differ by sex, with caspase activation potentially predominant in females after stroke.
Does pan-caspase inhibition reduce infarct volume and neurological deficits in male and female mice after stroke?
Population
Young and aging C57BL/6 mice of both sexes with focal stroke induced by reversible middle cerebral artery occlusion
Comparison
Pan-caspase inhibitor quinoline-Val-Asp(Ome)-CH2-O-phenoxy vs vehicle
Design
Preclinical experimental study
Follow-up
48 hours
Authors
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Sex differences in rodent stroke cell death pathways may inform targeted models; leaves open human translation.
Does pan-caspase inhibition reduce infarct volume and neurological deficits in male and female mice after stroke?
Caspase inhibition provides neuroprotection after stroke in female but not male mice, highlighting sex-specific cell death pathways and the need for sex-specific neuroprotective strategies.
Liu et al. (2009) studied Stroke. Quinoline-Val-Asp(Ome)-CH2-O-phenoxy vs. Vehicle was evaluated on Infarct volumes and neurological deficits. Pan-caspase inhibition with quinoline-Val-Asp(Ome)-CH2-O-phenoxy significantly decreased infarct volumes and improved neurological deficits in female mice, but had no effect in male mice.
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