Key result
Plasma NRG-1 drops after primary PCI in STEMI and remains low with no LVEF link.
Why the study?
Reduced myocardial damage and elevated Neuregulin-1 (NRG-1) after remote ischemic conditioning had been observed in rats, but the role of NRG-1 in patients with acute myocardial infarction remained unknown.
Is there an association between plasma Neuregulin-1 levels and cardiac function or remote ischemic conditioning in patients with STEMI?
Observational (n=30)
Is there an association between plasma Neuregulin-1 levels and cardiac function or remote ischemic conditioning in patients with STEMI?
p-value: p=<0.0001
In a small post hoc analysis of STEMI patients, plasma Neuregulin-1 levels were not associated with left ventricular ejection fraction, total ischemic time, or remote ischemic conditioning.
BACKGROUND: Neuregulin-1 (NRG-1) is a stress-mediated transmembrane growth factor. Reduced myocardial damage and higher NRG-1 levels upon treatment with remote ischemic conditioning (RIC) has been described in rats. However, the role of NRG-1 in patients with acute myocardial infarction (MI) is unknown. Thus, we conducted a post hoc analysis of a randomized controlled trial that tested RIC in patients with MI scheduled for primary percutaneous coronary intervention (PCI). METHODS: Blood was drawn from 30 patients before RIC/PCI, within 1 hour, 4 days and 1 month later. Median left ventricular ejection fraction (LVEF) in the overall study population following MI was 48.5%. RESULTS: < 0.0001). We observed no association of NRG-1 with other variables, including total ischemic time, LVEF or RIC. CONCLUSIONS: Thus, we identified NRG-1 may be independently affected by MI. However, further large clinical trials are warranted to clarify this hypothesis.
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Haller et al. (2022) conducted an observational in ST-elevation myocardial infarction (n=30). Acute ST-elevation myocardial infarction and primary PCI vs. Baseline (at presentation) was evaluated on Change in plasma Neuregulin-1 (NRG-1) levels over time (p=<0.0001). Plasma Neuregulin-1 levels decreased significantly following primary PCI in patients with acute STEMI and remained decreased up to 1 month (p < 0.0001), showing no association with left ventricular ejection fraction.
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