Key result
Inherited thrombophilia is found in ~13% of women with recurrent miscarriage.
Why the study?
The cause of recurrent miscarriage remains unexplained in 30% to 50% of cases, and the association of inherited thrombotic factors with RM patients has not been documented in northern India.
What is the prevalence of inherited thrombophilia in patients with recurrent miscarriages in north India?
Observational (n=40)
No
What is the prevalence of inherited thrombophilia in patients with recurrent miscarriages in north India?
Factor V Leiden mutation and protein S deficiency appear to be associated with a subset of patients with recurrent miscarriage in north India.
Answers are grounded in this paper and cite their sources.
May support thrombophilia screening in northern Indian RM; hypothesis-generating and requires prospective validation before practice change.
The cause of recurrent miscarriage (RM) remains unexplained in approximately 30% to 50% cases. The association of inherited thrombotic factors and RM patients has not been documented from the northern part of India. A total of 40 patients had been investigated for inherited thrombophilia workup (protein C, protein S [PS], antithrombin III, and factor V Leiden [FVL] mutation) over a period of 10 years (2005 to 2014). RM patients were divided in to three groups. Group I (only 1st trimester loss), group II (only 2nd and 3rd trimester), and group III (mixed). Each group comprised of the following numbers of patients respectively: I, 24; II, 2; III, 14. Heterozygous FVL mutation was found in 10% (4/40) cases. PS deficiency was detected in 2.7% (1/37) cases. In the present study FVL and PS were seems to be associated with a subset of patients however further studies with larger numbers of patients are recommended for better evaluation.
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Kumar et al. (2015) conducted an observational in Recurrent miscarriage (n=40). Inherited thrombophilia markers (Factor V Leiden, Protein S, Protein C, Antithrombin III) was evaluated on Prevalence of inherited thrombophilia abnormalities. Inherited thrombophilia abnormalities were found in 12.5% of women with recurrent miscarriage, including 10% with heterozygous Factor V Leiden mutation and 2.7% with Protein S deficiency.
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