An overview of the use of microemulsions as eluents in HPLC is given. The separation mechanisms involved are discussed and the technique is compared to solvent modified micellar chromatography as well as to ordinary reversed‐phase HPLC in order to evaluate differences and similarities. The microemulsion systems have been used for the separation of a number of antihypertensives and non steroidal antiinflammatory drug substances as well as for the analysis of bumetanide and acebutolol in plasma and urine. The plasma samples may be injected directly onto the HPLC system after a simple dilution.
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El‐Sherbiny et al. (2003) studied this question.
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