We propose flexible group sequential designs using type I and type II error probability spending functions. The proposed designs preserve the overall significance level and power and allow the repeated testing to be perloimed at a flexible schedule. Computational methods are described. An example on a mega clinical trial is provided.
No takes yet. Share an insight, caveat, or question.
Chang et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: